Superior efficacy in arresting and reversing caries

Colgate® Maximum Cavity Protection plus Sugar Acid Neutralizer™ Toothpaste—proven efficacy to arrest and reverse caries by 20%.

Study 1 of 2

Colgate® Maximum Cavity Protection plus Sugar Acid Neutralizer™—superior improvement in caries compared to a regular toothpaste with sodium fluoride. 

  • To view 3- month study results.

    Red Line

    1.5% Arginine/1450 ppm fluoride as sodium monofluorophosphate
    (MFP) in a calcium base

    Blue LIne

    1450 ppm fluoride as sodium fluoride (NaF) in a silica base

    Black Line

    Non-fluoride toothpaste in a calcium base

  • To view 6- month study results.

     

    GROUP

    Baseline ΔQ

    3 months ΔQ

    6 months ΔQ

    Red Line

    26.75

    17.64

    13.12

    Blue Line

    28

    21.24

    18.46

    Black Line

    27.02

    24.32

    23.54
Study 2 of 2

Reduction of caries at six months 

% of Subjects

any improvement

at  least 10%

at  least 20%

at  least 30%

at  least 40%

at  least 50%

Red Line

1.5% Arginine/1450 ppm fluoride as sodium monofluorophosphate

(MFP) in a calcium base

88.9

84.8

80.1

68.4

61.3

47.2

 

Blue Line

1450 ppm fluoride as sodium fluoride (NaF) in a silica base

78.9

73.4

64.9

56.4

49.5

39.5

Black Line
Non-fluoride toothpaste in a calcium base

70.7

67.2

60.6

50.2

40.2

34.0

  • Participants

    Male and female children aged 9 to 13 years, from 5 schools in Chengdu with at least one visible white spot lesion on the buccal surface of 1 of the 6 upper anterior teeth.

  • Methodology

    3 to 5 images per subject were taken of the upper anterior teeth, using a QLF imaging system, so that clear views of any lesions could be captured.

    Images were taken at baseline, and after 3 and 6 months use of the assigned

  • Conclusion

    A new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions than a conventional 1450 ppm fluoride alone.

  • Publication

    The Anti-caries Efficacy of a Dentifrice Containing 1.5% Arginine and 1450 ppm Fluoride as Sodium Monofluorophosphate Assessed Using Quantitative Light-induced Fluorescence (QLF)

    W. Yin, D.Y. Hu, X. Li, X. Fan, Y.P. Zhang, I.A. Pretty, L.R. Mateo, D. Cummins, R.P. Ellwood

    In: J Dent. 2013; 41S: 22-28